LAWRENCE BROXMEYER, MD
Lawrence Broxmeyer is a physician and medical researcher. He was on staff at New York affiliate hospitals of SUNY Downstate, Cornell University, and New York University for approximately fourteen years. In conjunction with colleagues in San Francisco and at the University of Nebraska, he first pursued, as lead author and originator, a novel technique to kill AIDS mycobacteria and tuberculosis, producing outstanding results (see Journal of Infectious Diseases 186, no. 8 (October 15, 2002): 1155-–60). Recently he contributed a chapter regarding these findings to Sleator and Hill’s textbook Patho-biotechnology, published by Landes Bioscience. In addition, Broxmeyer has written many peer-reviewed articles, available on PubMed of the US Library of Medicine, National Institutes of Health, at: http://www.ncbi.nlm.nih.gov/pubmed?term=broxmeyer%20L. Broxmeyer’s research covers the most challenging medical problems of our times, including AIDS, Alzheimer’s disease, and now autism.
News and Information
Book: Alzheimer's Disease—How Its Bacterial Cause Was Found and Then Discarded by by Lawrence Broxmeyer, MD
"The author is an internist and a medical researcher, and his double mastery of both the scientific minutiae and historical nuances of his subject matter is breathtaking. This is more than an account of a scientific debate--it's also an examination of the sometimes--unempirical way that such debate proceeds, as it's conducted by human beings with agendas of their own. Although it's a relatively short book--less than 200 pages of text--it is by no means a quick read. Nevertheless, readers with strong science backgrounds will be impressed by the author's undeniable competence, as well as his journalistic approach to chartering the evolution of thought regarding one of our era's most challenging diseases."
Book: AUTISM: An Ancient Foe Becomes a Modern Scourge
—The Return of a Stealth Bacteria
by Lawrence Broxmeyer Title ID: 3914659 ISBN- 13:978-1478101260
The consensus that autism is from an intrauterine infection is from an intrauterine infection is growing, bolstered by Patterson's and Fatemi's studies. However, the question still unanswered remains: which infection? This, of course is unknown. But in Autism: An Ancient Foe, a prime, conceivable candidate is logically presented and compelling supported by scientific literature, old and new. Until 1980 autism is still called "childhood schizophrenia" and in some parts of the world, it still is. By the same token, an extensive body of medical literature has tied schizophrenia to mycobacterial disease, the infectious focus of this book. This was only brought more sharply into focus when Rzhetsky, in 2007, used a proof-of-concept biostatistical analysis of 1.5 million patient records to find significant genetic overlap in humans with autism, schizophrenia......and tuberculosis. To this effect NIMH trials, presently ongoing, will determine whether the anti-tubercular drug Seromycin helps to diminish the symptomatology of autism as it did in animal models.
In a sense, this connection is hardly a new one. As early as 1887, John Langdon Down, a subset of whose 'developmentally disabled' children were autistic, saw this infection "for the most part" as resulting from parenteral tuberculosis.
Ann Arbor pathologist A.S. Warthin, appearing in the Journal of Infectious Diseases, suggested that even a woman with silent foci of tuberculosis in her body, and with no symptoms, could experience reactivation of her disease upon becoming pregnant. That, in turn, could transmit blood-borne TB bacilli to her unborn child. In fact, Warthin emphasized, this sort of transmission was not only possible, but common. Warthin saw silent asymptomatic tuberculosis during pregnancy a 'very grave danger' to the fetus. He also mentions that tubercle bacilli can pass through the placenta into fetal circulation without causing changes to either placental structure, or actual fetal tissue. In such cases, it could only be found in fetal blood- where it could remain undetected, while - as J.F. Schoeman would later argue - it could cause the sort of neonatal brain lesions that lay behind all neurodevelopmental disorders, including autism.
But TB has been "eradicated", right? Hardly, Broxmeyer explains. While tuberculosis is not generally regarded in the West as a killer disease, it once was - according to the World Health Organization, TB presently affects over one-third of the world's inhabitants. Even in the twenty-first century, globally, at least one person is infected with tuberculosis per second and someone dies of TB every ten seconds. Tuberculosis kills 2-3 million people each year, more than any other infectious disease in the world.
Eight years in the making, An Ancient Foe is a short and fascinating read that is equal parts science, history and whodunit. Broxmeyer's meticulously-documented biography of the disease weaves back and forth in time and place like a Ken Burns film edited by Tarantino. Readers leap from the modern day back to the 1800's, forward to the 1930s, and then back again as Broxmeyer spins his tale and makes his case. Along the way, he explores the little-known historic connection between autism, schizophrenia, and tuberculosis, and explains in layman's terms the complex series of steps, missteps, and steps-left-untaken that have allowed autism's "stealth pathogen" to evade modern diagnostics for decades.